|
KMID : 1234920210210020059
|
|
Journal of Korean Oriental Association for Study of Obesity
2021 Volume.21 No. 2 p.59 ~ p.68
|
|
|
Anti-Obesity and Anti-Diabetic Effects of a Polyherbal Extract Consisting of Coptidis Rhizoma, Salviae Miltiorrhizae Radix, and Cinnamomi Cortex in High Fat Diet-Induced Obesity Mice
|
|
Jung Su-Min
Kwon Se-Eun
Kang Seok-Yong
Kim Su-Jin
Jung Hyo-Won
Park Yong-Ki
|
|
|
Abstract
|
|
|
Objectives: We investigated the effects of Clean-DM4 (C-DM4), a polyherbal extract consisting of Coptidis Rhizoma, Salviae Miltiorrhiza Radix, and Cinnamomi Cortex on high fat diet (HFD)-induced obesity and diabetes in mice.
Methods: The C57BL/6 mice (6 weeks) were fed a HFD for 8 weeks and then administrated with C-DM4 extract at 500 mg/kg (p.o.) once daily for 4 weeks. The changes of body weights, calorie intakes, and fasting blood glucose (FBG) levels were measured in mice. The serum levels of glucose, insulin, total cholesterol, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were measured in mice by enzyme-based assay. It was also observed the histological changes of pancreas, liver, and fat tissues with hematoxylin and eosin (H&E) staining.
Results: The increase of calorie intakes and FBG levels in HFD-induced obesity mice was significantly decreased by oral administration of C-DM4 extract. C-DM4 extract administration was significantly reduced the increased levels of glucose, insulin, total cholesterol, AST, and ALT in obesity mice. In addition, C-DM4 extract inhibited lipid droplet accumulation in liver tissues of obesity mice, hyperplasia of pancreatic islets, and enlargement of adipocytes in adipose tissues.
Conclusions: Our study indicates that C-DM4 extract could help improve obesity and to prevent diabetes progression.
|
|
|
KEYWORD
|
|
|
Obesity, Type 2 diabetes mellitus, High-fat diet, Coptidis rhizoma extract, Salvia Miltiorrhiza, Cinnamomi Cortex
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|